If I remember correctly, Lysergacide had LSD as something ubiquitous. However, and while that may be true despite this, I think a 1920s LSD would open the door perfectly to a "Reefer Madness" type reaction from conservatives and moral crusaders wishing to ban it. Legitimately, LSD can give the same reactions the paranoid propaganda said marijuana would give you. And there's no reason to think the same BS would get pulled about LSD as it did in the OTL (hippies putting their babies in the oven instead of the roast, etc). Unless you take into account that propaganda line was born out of the instilled cultural subconscious from the anti-marijuana crusades of the 30s...it gets complicated.
They were banning drugs left and right during your great grandfather's day, and not for any reason. It was all paranoia. Largely it was also racism. Cocaine was banned because of the Southern trope of the "Cocaine Crazed Negro" that filled the headlines. Marijuana was banned because Mexicans smoked it, or were considered to smoke it, and especially come the Depression when men needed work, people wanted an excuse to throw the Mexicans out of the country. It's not just bigotry, but bigotry had a big role in all those bans.
There's a documentary on the history of various drugs the History Channel did. I recommend finding it.
This brings me to another topic I have written about previous, which is that while the 1920s were libertine, the 1930s were decidedly more conservative. It's an odd thing to consider at first, because the 1920s politics were Conservative, and the 1930s were Liberal. But the 30s had a cultural Conservatism that the 1920s did not. It was the period during which the moral crusaders had won and put the Hays Code in place, which retarded American artistic progress for decades and reinforced accepted racial stereotypes and other negatives. Before the Hays Code, movies could and did have swearing, maybe nudity, and while there were racist films, there were also very progressive films concerning race and gender. Those films also could have moral complexities and ambiguities you would not see when the Hays Code came, and the bad guys always had to be bad, the good guys good, and the bad guys had to lose at the end (put and asterisk there because they did manage to get away with it. See the Noire genre). The 1930s were also the period of keeping your head down and trying to survive, and that's probably where the conservatism comes from.
Bearing that in mind, for whatever libertine treatment LSD would get, or any ubiquitous of it, I'd say the 1930s, following the Depression, would be the period during which there would be a serious clamping down. If not sooner. Think 1970s compared to 1960s, perhaps.
EDIT:
Concerning music, I recommend looking at this if interested in the dynamic of the era, and to see why I keep bringing up Paul Whiteman.
http://www.elijahwald.com/beatlespop.html