The real OTL difference is the potential Personal Union with England and Scotland, and possibly a different, less hostile, relationship between Eduard and the Maid of Norway. Remember Edward II's otl wife was a major factor in his deposition and death. Maybe this won't happen here..?
Also...
As a DnD player, I both love and hate Gaming Dice. They allow us to experience wonderful things, but they will betray you every possible chance they can get!
And also to the perfect storm that that was Charles V standing on the Pope's neck through the whole thing. If not for Charles V and the mess in Italy at the time, the Annulment would probably have gone through with no trouble...